- Title
- When is research clinical advice? interpreting an exploratory study of paracetamol overdose
- Creator
- Isbister, Geoffrey K.; Duffull, Stephen Brent
- Relation
- Clinical Toxicology Vol. 51, Issue 10, p. 1242-1242
- Publisher Link
- http://dx.doi.org/10.3109/15563650.2013.857780
- Publisher
- Informa Healthcare
- Resource Type
- journal article
- Date
- 2013
- Description
- We conclude that the reported dose can be used as a predictor of patients who may require N-acetylcysteine (NAC), which can improve risk assessment. We do not provide any hard and fast recommendation, but discuss some scenarios where this analysis could be used to influence clinical practice. For example, the reported dose could potentially allow earlier administration of NAC in large overdoses where NAC is usually not commenced until a paracetamol concentration is available. Our suggestion of 50 g is an arbitrary value chosen to make a discussion, and 100 g, 60 g or 30 g could also have been chosen to illustrate the same point. The converse example is that some countries treat all patients ingesting paracetamol with NAC, so this study could allow the more targeted use of NAC, rather than treating all patients. Finally, paracetamol concentrations are either not available or difficult to access in many resource poor countries, and this study could potentially improve the risk assessment where dose may be the only information available.
- Subject
- paracetemol overdose; reported dose; paracetemol poisoning
- Identifier
- http://hdl.handle.net/1959.13/1045396
- Identifier
- uon:14454
- Identifier
- ISSN:1556-3650
- Language
- eng
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